MPS II: Clinical data







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The case for MPOD

Beatty et al (1999) Macular pigment and age related macular degenerationBritish Journal of Ophthalmology 83, 867–877

Beatty et al (2001) Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Investigative Ophthalmology & Visual Science 42(2), 439-46

Bernstein et al (2010) The value of measurement of macular carotenoid pigment optical densities and distributions in age-related macular degeneration and other retinal disorders. Vision Research 50(7), 716-28

Howells et al (2013) Macular Pigment Optical Density in Young Adults of South Asian OriginInvestigative Ophthalmology & Visual Science 54, 2711-2719

Korb et al (2014) Prevalence of age-related macular degeneration in a large European cohort: Results from the population-based Gutenberg Health Study. Graefe’s Archive for Clinical and Experimental Ophthalmology 252(9) 1403-11

Loane et al (2008) The rationale and evidence base for a protective role of macular pigment in age-related maculopathy. British Journal of Ophthalmology 92, 1163-1168

Tang et al (2004) Macular pigment optical density in young Chinese adultsOphthalmic & Physiological Optics 24, 586–593

Wooten, BR & Hammond, BR (2002) Macular pigment: influences on visual acuity and visibilityProgress in Retinal and Eye Research 21 (2002) 225–240

Lutein/Zeaxanthin supplementation

Age-Related Eye Disease Research Study (AREDS) – results (2001)

Age-Related Eye Disease Research Study 2 (AREDS2) – results (2013)

Berendschot et al (2000) Influence of Lutein Supplementation on Macular Pigment, Assessed with Two Objective Techniques. Clinical and Epidemiologic Research 41(11), 3322-3326

Bone, R (2003) Lutein and Zeaxanthin Dietary Supplements Raise Macular Pigment Density and Serum Concentrations of these Carotenoids in Humans.  Journal of Nutrition 133(4), 992-998

Davis, R.L. (2016) Preliminary Results in Macular Pigment Optical Density Associated with and without Zeaxanthin and Lutein Supplementation. Advances in Ophthalmology & Visual System 2(6)

Delcourt et al (2006) Plasma Lutein and Zeaxanthin and Other Carotenoids as Modifiable Risk Factors for Age-Related Maculopathy and Cataract: The POLA Study. Investigative Ophthalmology & Visual Science 47(6) 2329-35

Hammond et al (2014). A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on photostress recovery, glare disability and chromatic contrast. Investigative Ophthalmology and Visual Science 55(12) 8583-8589

Herman et al (2017) Case Report of Dietary Supplements Improving Macular Pigment and Visual Function. Advances in Ophthalmology & Visual System 6(1)

Maci, S & Santos, R (2015) The beneficial role of lutein and zeaxanthin in cataractsNutrafoods 14, 63-69

Murray et al (2013) Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLEAR study. Investigative Ophthalmology & Visual Science 54(3), 1781-88

Richer et al (2012) Retinal Spectral Domain Optical Coherence Tomography in Early Atrophic Age-Related Macular Degeneration (AMD) and a New Metric for Objective Evaluation of the Efficacy of Ocular NutritionNutrients 4, 1812-1827

MPS II*

Davey et al (2016) Macular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance. Clinical Ophthalmology (10) 1671-78

de Kinkelder et al (2011) Macular pigment optical density measurements: evaluation of a device using heterochromatic flicker photometry. Eye 25(1) 105-12

Howells et al (2013) Improving the repeatability of heterochromatic flicker photometry for measurement of macular pigment optical densityGraefe’s Archive for Clinical and Experimental Ophthalmology 251(3), 871-80

Murray, I, Makridaki, M & Carden, D (2011, April) Measuring MP in practice. Optician, 15-17

Neelam et al (2005) Measurement of Macular Pigment: Raman Spectroscopy versus Heterochromatic Flicker PhotometryInvestigative Ophthalmology & Visual Science 46(3), 1023-1032

Richer et al (2012) Macular Re-pigmentation Enhances Driving Vision in Elderly Adult Males with Macular Degeneration. Clinical & Experimental Ophthalmology 3(3)

Van der Veen et al (2009) A new desktop instrument for measuring macular pigment optical density based on a novel technique for setting flicker thresholds. Ophthalmic & Physiological Optics 29(2), 127-137

Zeaxanthin and Visual Function Study (ZVF) – results (2007)

*MPS II is re-badged as QuantifEye MPS II for sale in the United States

Other risk factors

Adams et al (2012) 20/20—Alcohol and Age-related Macular Degeneration: The Melbourne Collaborative Cohort StudyAmerican Journal of Epidemiology 176 (4), 289-298

Velilla et al (2013) Smoking and Age-Related Macular Degeneration: Review and UpdateJournal of Ophthalmology 2013, 895147

Zhang et al (2016) Overweight, Obesity, and Risk of Age-Related Macular DegenerationInvestigative Ophthalmology & Visual Science, Vol.57(3), 1276-1283